The Use of a Staggered Herringbone Micromixer for the Preparation of Rigid Liposomal Formulations Allows Efficient Encapsulation of Antigen and Adjuvant.

Lozano Vigario, Fernando; Nagy, Noémi Anna; The, Meike H; Sparrius, Rinske; Bouwstra, Joke A; Kros, Alexander; Jiskoot, Wim; de Jong, Esther C; Slütter, Bram

Lozano Vigario, Fernando; Nagy, Noémi Anna; The, Meike H; Sparrius, Rinske; Bouwstra, Joke A; Kros, Alexander; Jiskoot, Wim; de Jong, Esther C; Slütter, Bram.

Afiliação

Lozano Vigario F; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, the Netherlands.
Nagy NA; Department of Experimental Immunology, Amsterdam University Medical Centre, Amsterdam Institute for Infection & Immunity, University of Amsterdam, Amsterdam, the Netherlands.
The MH; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, the Netherlands.
Sparrius R; Department of Experimental Immunology, Amsterdam University Medical Centre, Amsterdam Institute for Infection & Immunity, University of Amsterdam, Amsterdam, the Netherlands.
Bouwstra JA; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, the Netherlands.
Kros A; Department of Supramolecular & Biomaterials Chemistry, Leiden Institute of Chemistry, Leiden University, the Netherlands.
Jiskoot W; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, the Netherlands.
de Jong EC; Department of Experimental Immunology, Amsterdam University Medical Centre, Amsterdam Institute for Infection & Immunity, University of Amsterdam, Amsterdam, the Netherlands.
Slütter B; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, the Netherlands. Electronic address: b.a.slutter@lacdr.leidenuniv.nl.

J Pharm Sci ; 111(4): 1050-1057, 2022 04.

Article em En | MEDLINE | ID: mdl-35114210

Assuntos

Lipossomos; Microfluídica; Adjuvantes Imunológicos; Adjuvantes Farmacêuticos; Lipídeos/química; Lipossomos/química; Microfluídica/métodos; Peptídeos

Palavras-chave

Herringbone micromixer; Liposomes; Microfluidics; Rigidity; Tolerance; Vitamin D3

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microfluídica / Lipossomos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microfluídica / Lipossomos Idioma: En Ano de publicação: 2022 Tipo de documento: Article