Cross-dressing of dendritic cells strengthens antitumor immunity.
Trends Cancer
; 8(3): 159-160, 2022 03.
Article
em En
| MEDLINE
| ID: mdl-35115254
ABSTRACT
Different subsets of tumor-infiltrating dendritic cells (DCs) influence immune response and tolerance in cancer settings. Duong et al. discovered that conventional DC2 subset (cDC2s) can differentiate into stimulatory interferon-stimulated gene (ISG)+ DCs by type I interferon (IFN-I) produced in regressor tumors and acquire and present tumor-derived peptide-MHC (pMHC) class I complexes to increase the protective antitumor CD8+ T cell response.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Linfócitos T CD8-Positivos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article