Prenatal Androgen Exposure and Traits of Autism Spectrum Disorder in the Offspring: Odense Child Cohort.
J Autism Dev Disord
; 53(3): 1053-1065, 2023 Mar.
Article
em En
| MEDLINE
| ID: mdl-35124780
ABSTRACT
Fetal androgen exposure may be associated with autism spectrum disorder (ASD). We studied 1777 mother-child pairs in the prospective Odense Child Cohort. Prenatal androgen exposure was assessed by maternal 3rd trimester testosterone concentrations, maternal polycystic ovary syndrome (PCOS), and 3 months offspring anogenital distance. ASD traits were assessed at age 3 years with the ASD-symptom scale of the Child Behavior Checklist for ages 1½-5 years. Maternal testosterone was positively associated with traits of ASD in boys (p < 0.05). Maternal PCOS was associated with increased offspring ASD traits (p = 0.046), but became non-significant after excluding parental psychiatric diagnosis. Offspring anogenital distance was not linked to ASD traits. Higher prevalence of ASD in boys could be linked to higher susceptibility to fetal androgen exposure.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
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Efeitos Tardios da Exposição Pré-Natal
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Transtorno do Espectro Autista
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article