Correlation between Reference Tissue Normalized 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Standardized Uptake Value Max of Nodal and Extranodal Sites in Lymphomas: An Empirical Study.

CONTEXT: Extranodal (EN) lymphomas involve sites other than lymph nodes (LNs), spleen, thymus, and the pharyngeal lymphatic ring. The highest standardized uptake value (SUV) max of the LN can aid in the diagnosis of EN site lymphomatous infiltrations over inflammation or infection especially when there are no contrast-enhanced computed tomography (CT) changes. AIMS: The purpose of this study was to find the significance of correlation between absolute SUVmax and mediastinal blood pool (mbSUVmax) and liver (lvSUVmax) normalized SUVmax of EN sites and the most fluorodeoxyglucose (FDG) avid LN in patients with primary and secondary EN involvement in Non-Hodgkin's and Hodgkin's Lymphoma. SETTINGS AND DESIGN: This was a retrospective study of 70 patients with histopathologically proven lymphoma in whom 18F-FDG positron emission tomography CT was performed for pretherapy staging. MATERIALS AND METHODS: Images were used to detect EN sites of disease and SUVmax of mediastinal blood pool, liver, highest SUVmax LN, and highest SUVmax EN site were calculated. STATISTICAL ANALYSIS USED: Karl Pearson's coefficient of correlation (r) was used to correlate the highest SUV max of LN and EN site and corresponding highest blood pool corrected and liver corrected SUV max. In view of small sample size, t-test for paired samples at 5% and 10% significance was conducted to validate the findings. Two-tailed t-test for independent samples was also used to compare means of SUVmax values between data grouped according to gender and lymphoma subtype (Non-Hodgkin lymphoma and Hodgkin lymphoma). RESULTS: r = 0.54 for the highest LN SUVmax-highest EN SUVmax values and on further validation by one- and two-tailed paired t-test at significance levels of 5% and 10%, P = 0.00052 and 0.00103 respectively which denoted significant positive and moderate correlation. r = 0.59 for highest LN lvSUVmax-highest EN vSUVmax and P = 0.00032 and 0.00065 showing positive and moderate correlation. r = 0 0.82 for highest LN mbSUVmax-highest EN mbSUVmax values and P = 0.00034 and 0.00068 revealing positive and strong correlation. CONCLUSION: Significant positive and strong correlation exists between nodal and EN mbsUVmax. This is stronger than the correlation between nodal and EN absolute SUVmax and lvSUVmax. Since normalization of lesion SUVmax to reference tissues reduces the variability of SUV, this can be a useful adjunct to determine whether high SUVmax of the EN site is due to lymphomatous infiltration.