Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions.
J Vis Exp
; (179)2022 01 20.
Article
em En
| MEDLINE
| ID: mdl-35129172
ABSTRACT
The Glyco@Expasy initiative was launched as a collection of interdependent databases and tools spanning several aspects of knowledge in glycobiology. In particular, it aims at highlighting interactions between glycoproteins (such as cell surface receptors) and carbohydrate-binding proteins mediated by glycans. Here, major resources of the collection are introduced through two illustrative examples centered on the N-glycome of the human Prostate Specific Antigen (PSA) and the O-glycome of human serum proteins. Through different database queries and with the help of visualization tools, this article shows how to explore and compare content in a continuum to gather and correlate otherwise scattered pieces of information. Collected data are destined to feed more elaborate scenarios of glycan function. Glycoinformatics introduced here is, therefore, proposed as a means to either strengthen, shape, or refute assumptions on the specificity of a protein glycome in a given context.
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Base de dados:
MEDLINE
Assunto principal:
Biologia Computacional
/
Glicômica
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article