Chemoselective Transformations of Cyclic ß-Bromoacrylic Acids with Palladacycles Formed by Aryl Iodides to Access Fused or Spiro Polycycles.
Org Lett
; 24(6): 1400-1404, 2022 Feb 18.
Article
em En
| MEDLINE
| ID: mdl-35129360
ABSTRACT
A palladium-catalyzed chemoselective decarboxylative annulation of different aryl iodides with cyclic ß-bromoacrylic acids for the construction of interesting fused and spiro polycycles is disclosed. Notably, cyclic ß-bromoacrylic acids can chemoselectively act as C1 or C2 insertion units by the use of different aryl iodides. 2-Iodo-N-methacryloylbenzamides can undergo a Heck/[4+2] annulation to afford hexahydrodibenzoisoquinoline-4,6(5H)-diones. Employing 2-iodobiphenyls or N-(2-iodophenyl)-2-phenylacrylamides as substrates enables the assembly of spirofluorenes and dispirooxindoles.
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MEDLINE
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En
Ano de publicação:
2022
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Article