[Potential regulatory role of long non-coding RNA-microRNA-mRNA axis in sepsis].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
; 33(12): 1514-1518, 2021 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-35131023
ABSTRACT
Sepsis is a life-threatening multiple organ dysfunction disease with high mortality and has become leading causes of death affecting intensive care unit (ICU) patients. Both long non-coding RNA (lncRNA) and microRNA (miRNA) are involved in the pathophysiological process of sepsis and can regulate the inflammatory response, both of which could be used as important diagnostic indicators and therapeutic targets of sepsis. The interaction among lncRNA, miRNA and mRNA plays an important role in sepsis and multiple organ dysfunction. This paper reviewed the regulatory relationship of lncRNA, miRNA and mRNA, as well as the regulatory role of lncRNA-miRNA-mRNA axis in inflammatory immune response and multiple organ dysfunction syndrome in sepsis, to provide new targets and strategies for the treatment of sepsis and organ dysfunction.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sepse
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MicroRNAs
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RNA Longo não Codificante
Idioma:
Zh
Ano de publicação:
2021
Tipo de documento:
Article