Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants.
Signal Transduct Target Ther
; 7(1): 42, 2022 02 08.
Article
em En
| MEDLINE
| ID: mdl-35136040
ABSTRACT
SARS-CoV-2 variants have evolved a variety of critical mutations, leading to antigenicity changes and immune escape. The recent emerging SARS-CoV-2 Omicron variant attracted global attention due to its significant resistance to current antibody therapies and vaccines. Here, we profiled the mutations of Omicron and other various circulating SARS-CoV-2 variants in parallel by computational interface analysis and in vitro experimental assays. We identified critical mutations that lead to antigenicity changes and diminished neutralization efficiency of a panel of 14 antibodies due to diverse molecular mechanisms influencing the antigen-antibody interaction. Our study identified that Omicron exhibited extraordinary potency in immune escape compared to the other variants of concern, and explores the application of computational interface analysis in SARS-CoV-2 mutation surveillance and demonstrates its potential for the early identification of concerning variants, providing preliminary guidance for neutralizing antibody therapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anticorpos Neutralizantes
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Evasão da Resposta Imune
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SARS-CoV-2
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COVID-19
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Anticorpos Antivirais
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Antígenos Virais
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article