Outcomes in patients receiving palliative chemotherapy for advanced biliary tract cancer.
JHEP Rep
; 4(3): 100417, 2022 Mar.
Article
em En
| MEDLINE
| ID: mdl-35141511
ABSTRACT
BACKGROUND & AIMS:
Advanced biliary tract cancer (ABTC) is associated with a poor prognosis. Real-world data on the outcome of patients with ABTC undergoing sequential chemotherapies remain scarce, and little is known about treatment options beyond the established first- and second-line treatments with gemcitabine + cisplatin and FOLFOX. This study aimed to evaluate the outcome of patients with regard to different oncological therapies and to identify prognostic factors.METHODS:
From January 2010 until December 2019, 142 patients started palliative chemotherapy at our tertiary care liver center. Overall survival (OS) was calculated using Kaplan-Meier plots. Prognostic factors were evaluated using cox proportional-hazards.RESULTS:
Patients received a median number of 2 lines of chemotherapy. Median OS was 6.7, 15.2 and 18.2 months for patients who received 1, 2 and 3 lines of chemotherapy, respectively. Patients treated with FOLFIRINOX had a significantly extended OS of 23.8 months (log-rank test p = 0.018). The univariate cox regression analysis identified several clinical parameters associated with survival (e.g. albumin, bilirubin, carcinoembryonic antigen, carbohydrate antigen 19-9 levels).CONCLUSIONS:
Our study provides real-world data on the prognosis of ABTC including survival times for patients receiving third and later lines of chemotherapy. LAYSUMMARY:
Real-world data depicting the outcome of patients with advanced biliary tract cancer outside the framework of controlled trials remain rare despite being extremely important for clinical decision-making. This study therefore provides important real-world data on the established first- and second-line treatments with gemcitabine + cisplatin and FOLFOX, as well as on other chemotherapy regimens or later lines of chemotherapy. It further demonstrates that the use of FOLFIRINOX is associated with promising survival and that there is an association between various clinical parameters such as pre-therapeutic albumin, bilirubin or carbohydrate antigen 19-9 levels and survival.
ABTC, advanced biliary tract cancer; CA19-9, carbohydrate antigen 19-9; CEA, carcinoembryonic antigen; CT1, first-line chemotherapy; CT2, second-line chemotherapy; CT3, third-line chemotherapy; ECOG PS, Eastern Cooperative Oncology Group performance status; FGFR, fibroblast growth factor receptor; GBC, gallbladder cancer; GemCis, gemcitabine + cisplatin; GemOx, gemcitabine + oxaliplatin; IDH, isocitrate dehydrogenase; OS, overall survival; UICC, Union for International Cancer Control; cholangiocarcinoma; iCCA, intrahepatic cholangiocarcinoma; metastasis; pCCA, perihilar cholangiocarcinoma; primary liver cancer; survival; treatment
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article