Cardiovascular Risk Associated with Poorer Memory in Middle-Aged Adults from the Healthy Brain Project.
J Alzheimers Dis
; 86(3): 1081-1091, 2022.
Article
em En
| MEDLINE
| ID: mdl-35147538
ABSTRACT
BACKGROUND:
Midlife cardiovascular risk factors (CVRF) are associated with reduced cognition and an increased risk of dementia.OBJECTIVE:
To further investigate this association using remote unsupervised online assessment of cognition and cardiovascular risk in middle-aged adults; and to explore the extent to which the association is altered by carriage of the APOE É4 allele.METHODS:
The Healthy Brain Project is an online cohort of middle-aged cognitively unimpaired adults (40-70 years) who have undergone cognitive assessment and provided self-reports of demographic and health history. Cardiovascular risk was determined by ascertaining history of hypertension, hypercholesterolemia, diabetes mellitus, overweight (body mass index≥25), and current cigarette smoking. Participants (nâ=â2,480) were then grouped based on the number of reported CVRF into no CVRF, 1, 2, and≥3 CVRF. Associations between the number of CVRF as a continuous variable, CVRF group, and each individual CVRF with composite measures of attention, memory and subjective cognitive function were investigated.RESULTS:
Higher number of CVRF was associated with poorer attention (ß=â-0.042, pâ=â0.039) and memory (ß=â-0.080, pâ<â0.001), but not with subjective cognitive function. When considered individually, current smoking (ß=â-0.400, pâ=â0.015), diabetes (ß=â-0.251, pâ=â0.023), and hypercholesterolemia (ß=â-0.109, pâ=â0.044) were independently associated with poorer memory performance. APOE É4 carriers with≥1 CVRF performed worse on memory than É4 carriers with no CVRFs (ß(SE)â=â0.259(0.077), pâ=â0.004). This was not observed in É4 non-carriers.CONCLUSION:
In cognitively normal middle-aged adults, CVRF were associated with poorer cognition, particularly in the memory domain. These results support feasibility of online assessment of cardiovascular risk for cognitive impairment.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
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Diabetes Mellitus
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Hipercolesterolemia
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Hiperlipidemias
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article