Tumour mutational burden: an overview for pathologists.
Pathology
; 54(3): 249-253, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-35153070
ABSTRACT
Cancer immunotherapy holds great promise and has shown durable responses in many patients; however, these responses are not uniform in all patients or all tumour streams. There is an ongoing clinical need for objective diagnostic biomarkers to identify patients that will respond to immunotherapies. Tumour mutational burden (TMB) is a diagnostic biomarker that can stratify cancer patients for response to immune checkpoint inhibitor therapies. It is commonly defined as the average number of somatic mutations per megabase in a tumour exome. Here we describe the TMB biomarker, how it is determined, its underlying molecular basis, the relationship to neoantigens and the issues around its clinical use. This overview is directed toward practising pathologists wishing to be informed of this predictive biomarker.
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MEDLINE
Assunto principal:
Neoplasias
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article