The potential of long noncoding RNA therapies.
Trends Pharmacol Sci
; 43(4): 269-280, 2022 04.
Article
em En
| MEDLINE
| ID: mdl-35153075
ABSTRACT
The human genome expresses vast numbers of long noncoding RNAs (lncRNA) that fulfil diverse roles in gene regulation, cell biology, development, and human disease. These roles are often mediated by sequence motifs and secondary structures bound by proteins and can regulate epigenetic, transcriptional, and translational pathways. These functional domains can be further optimised and engineered into RNA devices that are widely used in synthetic biology. We propose that natural lncRNA structures can be explored and exploited for the rational design and assembly of synthetic RNA therapies. This potential has been enabled by advances in the stability, immunogenicity, manufacture, and delivery of other RNA-based therapies, from which we can anticipate the pharmacological properties of lncRNA therapies that have not yet otherwise entered clinical trials.
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Base de dados:
MEDLINE
Assunto principal:
RNA Longo não Codificante
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article