Niclosamide Ethanolamine Salt Alleviates Idiopathic Pulmonary Fibrosis by Modulating the PI3K-mTORC1 Pathway.

Pei, Xiaolin; Zheng, Fangxu; Li, Yin; Lin, Zhoujun; Han, Xiao; Feng, Ya; Tian, Zhenhuan; Ren, Dunqiang; Cao, Ke; Li, Chenggang

Pei, Xiaolin; Zheng, Fangxu; Li, Yin; Lin, Zhoujun; Han, Xiao; Feng, Ya; Tian, Zhenhuan; Ren, Dunqiang; Cao, Ke; Li, Chenggang.

Afiliação

Pei X; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China.
Zheng F; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China.
Li Y; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China.
Lin Z; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China.
Han X; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China.
Feng Y; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China.
Tian Z; Department of Thoracic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, China.
Ren D; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.
Cao K; Department of Pathophysiology, Jinzhou Medical University, Jinzhou 121001, China.
Li C; State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China.

Cells ; 11(3)2022 01 20.

Article em En | MEDLINE | ID: mdl-35159160

Assuntos

Fibrose Pulmonar Idiopática; Animais; Bleomicina/uso terapêutico; Etanolamina/efeitos adversos; Hidroxiprolina; Fibrose Pulmonar Idiopática/induzido quimicamente; Fibrose Pulmonar Idiopática/tratamento farmacológico; Fibrose Pulmonar Idiopática/metabolismo; Alvo Mecanístico do Complexo 1 de Rapamicina; Camundongos; Niclosamida/farmacologia; Niclosamida/uso terapêutico; Fosfatidilinositol 3-Quinases/metabolismo; Fator de Crescimento Transformador beta1/metabolismo

Palavras-chave

cell proliferation; epithelialmesenchymal transition; idiopathic pulmonary fibrosis; mTOR pathway; niclosamide ethanolamine salt

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar Idiopática Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar Idiopática Idioma: En Ano de publicação: 2022 Tipo de documento: Article