Epigenetics in the Diagnosis and Therapy of Malignant Melanoma.
Int J Mol Sci
; 23(3)2022 Jan 28.
Article
em En
| MEDLINE
| ID: mdl-35163453
ABSTRACT
Epigenetic mechanisms are fundamentally important for cancer initiation and development. However, a survey of the literature reveals that, to date, they appear less comprehensively investigated in melanoma than in many other cancers, e.g., prostate, breast, and colon carcinoma. The aim of this review is to provide a short summary of epigenetic aspects of functional relevance for melanoma pathogenesis. In addition, some new perspectives from epigenetic research in other cancers with potential for melanoma diagnosis and therapy are introduced. For example, the PrimeEpiHit hypothesis in urothelial carcinoma, which, similarly to malignant melanoma, can also be triggered by a single exogenous noxa, states that one of the first steps for cancer initiation could be epigenetic changes in key genes of one-carbon metabolism. The application of such insights may contribute to further progress in the diagnosis and therapy of melanoma, a deadly type of cancer.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Epigênese Genética
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Redes Reguladoras de Genes
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Melanoma
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article