MiR-1260b protects against LPS-induced degenerative changes in nucleus pulposus cells through targeting TCF7L2.

Chen, Shijie; Shi, Guixia; Zeng, Jin; Li, Ping Huang; Peng, Yi; Ding, Zhiyu; Cao, Hong Qing; Zheng, Ruping; Wang, Weiguo

Chen, Shijie; Shi, Guixia; Zeng, Jin; Li, Ping Huang; Peng, Yi; Ding, Zhiyu; Cao, Hong Qing; Zheng, Ruping; Wang, Weiguo.

Afiliação

Chen S; Department of Orthopaedics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Shi G; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Zeng J; Department of Internal Medicine, Changsha Health Vocational Collage, Changsha, 410100, Hunan, China.
Li PH; Department of Orthopaedics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Peng Y; Department of Orthopaedics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Ding Z; Department of Orthopaedics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Cao HQ; Department of Orthopaedics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Zheng R; Department of Orthopaedics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Wang W; School of Basic Medical Science, Central South University, Changsha, 410013, Hunan, China.

Hum Cell ; 35(3): 779-791, 2022 May.

Article em En | MEDLINE | ID: mdl-35165858

Assuntos

Degeneração do Disco Intervertebral; MicroRNAs; Núcleo Pulposo; Apoptose; Células Cultivadas; Matriz Extracelular/genética; Matriz Extracelular/metabolismo; Humanos; Degeneração do Disco Intervertebral/genética; Degeneração do Disco Intervertebral/metabolismo; Lipopolissacarídeos/farmacologia; MicroRNAs/genética; Proteína 2 Semelhante ao Fator 7 de Transcrição/genética; Proteína 2 Semelhante ao Fator 7 de Transcrição/metabolismo; Proteína 2 Semelhante ao Fator 7 de Transcrição/farmacologia

Palavras-chave

Intervertebral disc degeneration; Nucleus pulposus cells; Senescence; TCF7L2; miR-1260b

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Degeneração do Disco Intervertebral / Núcleo Pulposo Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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