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Update Breast Cancer 2021 Part 5 - Advanced Breast Cancer.
Lüftner, Diana; Schütz, Florian; Stickeler, Elmar; Fasching, Peter A; Janni, Wolfgang; Kolberg-Liedtke, Cornelia; Kolberg, Hans-Christian; Thomssen, Christoph; Müller, Volkmar; Fehm, Tanja N; Belleville, Erik; Bader, Simon; Untch, Michael; Welslau, Manfred; Thill, Marc; Tesch, Hans; Ditsch, Nina; Lux, Michael P; Wöckel, Achim; Aktas, Bahriye; Schneeweiss, Andreas; Würstlein, Rachel; Hartkopf, Andreas D.
Afiliação
  • Lüftner D; Charité University Hospital, Department of Hematology, Oncology and Tumour Immunology, University Medicine Berlin, Berlin, Germany.
  • Schütz F; Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany.
  • Stickeler E; Department of Gynecology and Obstetrics, RWTH University Hospital Aachen, Aachen, Germany.
  • Fasching PA; Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
  • Janni W; Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany.
  • Kolberg-Liedtke C; Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany.
  • Kolberg HC; palleos healthcare, Wiesbaden, Germany.
  • Thomssen C; Phaon Scientific, Wiesbaden, Germany.
  • Müller V; Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany.
  • Fehm TN; Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
  • Belleville E; Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany.
  • Bader S; Gynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer, Germany.
  • Untch M; ClinSol GmbH & Co KG, Würzburg, Germany.
  • Welslau M; Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
  • Thill M; Clinic for Gynecology and Obstetrics, Breast Cancer Center, Genecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin, Germany.
  • Tesch H; Onkologie Aschaffenburg, Aschaffenburg, Germany.
  • Ditsch N; Agaplesion Markus Krankenhaus, Department of Gynecology and Gynecological Oncology, Frankfurt am Main, Germany.
  • Lux MP; Oncology Practice at Bethanien Hospital, Frankfurt am Main, Germany.
  • Wöckel A; Department of Gynecology and Obstetrics, University Hospital Augsburg, Augsburg, Germany.
  • Aktas B; Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, St. Vincenz Krankenhaus GmbH, Paderborn, Germany.
  • Schneeweiss A; Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany.
  • Würstlein R; Klinik und Poliklinik für Gynäkologie, Universitätsklinikum Leipzig, Leipzig, Germany.
  • Hartkopf AD; National Center for Tumor Diseases (NCT), Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany.
Geburtshilfe Frauenheilkd ; 82(2): 215-225, 2022 Feb.
Article em En | MEDLINE | ID: mdl-35169389
ABSTRACT
Despite the COVID 19 pandemic and mostly virtual congresses, innovation in the treatment of breast cancer patients continues at an unabated pace. This review summarises the current developments. Initial overall survival data for CDK4/6 inhibitor treatment in combination with an aromatase inhibitor as the first advanced line of therapy in treatment-naive postmenopausal patients have been published. Similarly, a trial comparing trastuzumab-deruxtecan versus trastuzumab-emtansine revealed a clear benefit regarding progression-free survival. Understanding of biomarkers making checkpoint inhibitor therapy particularly effective is increasing, and new compounds such as oral selective estrogen receptor destabilisers (SERDs) are entering clinical development and completing the first phase III trials.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article