Distinct role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior.
Cell Rep
; 38(7): 110380, 2022 02 15.
Article
em En
| MEDLINE
| ID: mdl-35172164
ABSTRACT
The nucleus accumbens (NAc) is a key region in motivated behaviors. NAc medium spiny neurons (MSNs) are divided into those expressing dopamine receptor D1 or D2. Classically, D1- and D2-MSNs have been described as having opposing roles in reinforcement, but recent evidence suggests a more complex role for D2-MSNs. Here, we show that optogenetic modulation of D2-MSN to ventral pallidum (VP) projections during different stages of motivated behavior has contrasting effects in motivation. Activation of D2-MSN-VP projections during a reward-predicting cue results in increased motivational drive, whereas activation at reward delivery decreases motivation; optical inhibition triggers the opposite behavioral effect. In addition, in a free-choice instrumental task, animals prefer the lever that originates one pellet in opposition to pellet plus D2-MSN-VP optogenetic activation and vice versa for optogenetic inhibition. In summary, D2-MSN-VP projections play different, and even opposing, roles in distinct phases of motivated behavior.
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Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
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Receptores de Dopamina D2
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Prosencéfalo Basal
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Motivação
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Neurônios
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Núcleo Accumbens
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article