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A human pluripotent stem cell-based model of SARS-CoV-2 infection reveals an ACE2-independent inflammatory activation of vascular endothelial cells through TLR4.
Ma, Zhangjing; Li, Xisheng; Fan, Rebecca L Y; Yang, Kevin Y; Ng, Calvin S H; Lau, Rainbow W H; Wong, Randolph H L; Ng, Kevin K; Wang, Chi Chiu; Ye, Peng; Fu, Zelong; Chin, Alex W H; Lai, M Y Alison; Huang, Yu; Tian, Xiao Yu; Poon, Leo L M; Lui, Kathy O.
Afiliação
  • Ma Z; Department of Chemical Pathology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
  • Li X; Department of Chemical Pathology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
  • Fan RLY; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Yang KY; Department of Chemical Pathology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
  • Ng CSH; Department of Surgery, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
  • Lau RWH; Department of Surgery, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
  • Wong RHL; Department of Surgery, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
  • Ng KK; Department of Surgery, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
  • Wang CC; Department of Obstetrics & Gynaecology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; School of
  • Ye P; Department of Chemical Pathology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
  • Fu Z; Department of Chemical Pathology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
  • Chin AWH; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Lai MYA; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Huang Y; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
  • Tian XY; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China.
  • Poon LLM; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; HKU-Pasteur Research Pole, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. Electronic address: llmpoon@hku.hk.
  • Lui KO; Department of Chemical Pathology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; Shenzhen Research In
Stem Cell Reports ; 17(3): 538-555, 2022 03 08.
Article em En | MEDLINE | ID: mdl-35180397
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor 4 Toll-Like / Enzima de Conversão de Angiotensina 2 / SARS-CoV-2 / Modelos Biológicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor 4 Toll-Like / Enzima de Conversão de Angiotensina 2 / SARS-CoV-2 / Modelos Biológicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article