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IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET).
Nochi, Zahra; Pia, Hossein; Bloms-Funke, Petra; Boesl, Irmgard; Caspani, Ombretta; Chapman, Sonya C; Fardo, Francesca; Genser, Bernd; Goetz, Marcus; Kostenko, Anna V; Leone, Caterina; Li, Thomas; Mouraux, André; Pelz, Bernhard; Pogatzki-Zahn, Esther; Schilder, Andreas; Schnetter, Erik; Schubart, Karin; Stouffs, Alexandre; Tracey, Irene; Troconiz, Iñaki F; Truini, Andrea; Van Niel, Johannes; Vela, Jose Miguel; Vincent, Katy; Vollert, Jan; Wanigasekera, Vishvarani; Wittayer, Matthias; Tankisi, Hatice; Finnerup, Nanna B; Phillips, Keith G; Treede, Rolf-Detlef.
Afiliação
  • Nochi Z; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Pia H; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Bloms-Funke P; Translational Science & Intelligence, Grünenthal GmbH, Aachen, Germany.
  • Boesl I; Clinical Science Development, Grünenthal GmbH, Aachen, Germany.
  • Caspani O; Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, Mannheim, Germany.
  • Chapman SC; Eli Lilly and Company, Arlington Square, Bracknell, UK.
  • Fardo F; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Genser B; Mannheim Institute of Public Health, Social & Preventive Medicine, University of Heidelberg, Heidelberg, Germany.
  • Goetz M; MRC Systems GmbH, Heidelberg, Germany.
  • Kostenko AV; Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, Mannheim, Germany.
  • Leone C; Department of Human Neuroscience, Sapienza University, Rome, Italy.
  • Li T; Teva Branded Pharmaceutical Products R&D, Inc, West Chester, PA, USA.
  • Mouraux A; Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium.
  • Pelz B; MRC Systems GmbH, Heidelberg, Germany.
  • Pogatzki-Zahn E; Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
  • Schilder A; Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, Mannheim, Germany.
  • Schnetter E; University Computing Centre, University of Heidelberg, Heidelberg, Germany.
  • Schubart K; ConsulTech GmbH, Berlin, Germany.
  • Stouffs A; Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium.
  • Tracey I; Wellcome Centre for Integrative Neuroimaging, FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
  • Troconiz IF; Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
  • Truini A; Department of Human Neuroscience, Sapienza University, Rome, Italy.
  • Van Niel J; Mature Products Development, Grünenthal GmbH, Aachen, Germany.
  • Vela JM; Welab Barcelona, Barcelona, Spain.
  • Vincent K; Nuffield Department of Women's and Reproductive Health (NDWRH), University of Oxford, Oxford, UK.
  • Vollert J; Pain Research, Department of Surgery and Cancer, Imperial College London, London, UK.
  • Wanigasekera V; Wellcome Centre for Integrative Neuroimaging, FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
  • Wittayer M; Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, Mannheim, Germany.
  • Tankisi H; Department of Clinical Medicine, Aarhus University and Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.
  • Finnerup NB; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. finnerup@clin.au.dk.
  • Phillips KG; Neuroscience Next Generation Therapeutics, Eli Lilly and Company, Lilly Innovation Center, Cambridge, MA, USA.
  • Treede RD; Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, Mannheim, Germany.
Trials ; 23(1): 163, 2022 Feb 19.
Article em En | MEDLINE | ID: mdl-35183242

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Nervos Periféricos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Nervos Periféricos Idioma: En Ano de publicação: 2022 Tipo de documento: Article