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The future of circulating tumor DNA as a biomarker in HPV related oropharyngeal squamous cell carcinoma.
Haring, Catherine T; Dermody, Sarah M; Yalamanchi, Pratyusha; Kang, Stephen Y; Old, Matthew O; Chad Brenner, J; Spector, Matthew E; Rocco, James W.
Afiliação
  • Haring CT; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, OH, United States. Electronic address: Catherine.haring@osumc.edu.
  • Dermody SM; Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, MI, United States.
  • Yalamanchi P; Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, MI, United States.
  • Kang SY; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, OH, United States.
  • Old MO; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, OH, United States.
  • Chad Brenner J; Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, MI, United States.
  • Spector ME; Department of Otolaryngology-Head and Neck Surgery, Michigan Medicine, Ann Arbor, MI, United States.
  • Rocco JW; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, OH, United States.
Oral Oncol ; 126: 105776, 2022 03.
Article em En | MEDLINE | ID: mdl-35183912
Human papillomavirus (HPV) related oropharyngeal squamous cell carcinoma (OPSCC) is associated with improved outcomes compared to non-virally mediated disease. Clinical trials are actively investigating de-escalation strategies to maintain excellent survival outcomes while minimizing toxicity. Delivery of effective precision medicine-based therapeutic approaches are strengthened by the identification of biomarkers to predict treatment response. Plasma circulating tumor (ct) DNA is the most studied liquid biomarker in head and neck cancer and has shown great promise in the ability to determine treatment response and monitor for disease recurrence. In this review, we examine the emerging evidence for ctDNA as a biomarker in HPV related OPSCC and discuss opportunities for future investigation and integration into clinical practice.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma de Células Escamosas / Neoplasias Orofaríngeas / Infecções por Papillomavirus / Alphapapillomavirus / DNA Tumoral Circulante / Neoplasias de Cabeça e Pescoço Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma de Células Escamosas / Neoplasias Orofaríngeas / Infecções por Papillomavirus / Alphapapillomavirus / DNA Tumoral Circulante / Neoplasias de Cabeça e Pescoço Idioma: En Ano de publicação: 2022 Tipo de documento: Article