Indigodole E from Strobilanthes cusia exhibits anti-IL-17A effect.
Nat Prod Res
; 36(23): 5935-5939, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-35192387
ABSTRACT
One new indazole alkaloid, indigodole E (1), was isolated from a traditional Chinese medicine Qing Dai prepared from the aerial parts of Strobilanthes cusia. The structure of 1 was elucidated by NMR, MS, UV, and IR spectra as well as optical rotation. Additionally, compound 1 could obviously inhibit not only IL-17A protein production at concentrations from 1.25 to 2.5 µg/mL, but also IL-17 gene expression at concentrations from 5.0 to 10.0 µg/mL without cytotoxicity toward Th17 and Jukat cells, respectively. Overall, indazole analogue 1 could be the anti-IL 17 A contributor of Qing Dai in this investigation.
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Base de dados:
MEDLINE
Assunto principal:
Acanthaceae
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article