ACAGT-007a, an ERK MAPK Signaling Modulator, in Combination with AKT Signaling Inhibition Induces Apoptosis in KRAS Mutant Pancreatic Cancer T3M4 and MIA-Pa-Ca-2 Cells.

Khandakar, Golam Iftakhar; Satoh, Ryosuke; Takasaki, Teruaki; Fujitani, Kana; Tanabe, Genzoh; Sakai, Kazuko; Nishio, Kazuto; Sugiura, Reiko

Khandakar, Golam Iftakhar; Satoh, Ryosuke; Takasaki, Teruaki; Fujitani, Kana; Tanabe, Genzoh; Sakai, Kazuko; Nishio, Kazuto; Sugiura, Reiko.

Afiliação

Khandakar GI; Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Kindai University, Osaka 577-8502, Japan.
Satoh R; Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Kindai University, Osaka 577-8502, Japan.
Takasaki T; Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Kindai University, Osaka 577-8502, Japan.
Fujitani K; Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Kindai University, Osaka 577-8502, Japan.
Tanabe G; Laboratory of Organic Chemistry, Department of Pharmacy, Faculty of Pharmacy, Kindai University, Osaka 577-8502, Japan.
Sakai K; Department of Genome Biology, Kindai University School of Medicine, Osaka 589-8511, Japan.
Nishio K; Department of Genome Biology, Kindai University School of Medicine, Osaka 589-8511, Japan.
Sugiura R; Laboratory of Organic Chemistry, Department of Pharmacy, Faculty of Pharmacy, Kindai University, Osaka 577-8502, Japan.

Cells ; 11(4)2022 02 17.

Article em En | MEDLINE | ID: mdl-35203351

Assuntos

Carcinoma Ductal Pancreático; Neoplasias Pancreáticas; Apoptose; Carcinoma Ductal Pancreático/tratamento farmacológico; Carcinoma Ductal Pancreático/genética; Linhagem Celular Tumoral; Humanos; Proteínas Quinases Ativadas por Mitógeno/metabolismo; Neoplasias Pancreáticas/tratamento farmacológico; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/metabolismo; Fosfatidilinositol 3-Quinase/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Proteínas Proto-Oncogênicas p21(ras)/genética; Proteínas Proto-Oncogênicas p21(ras)/metabolismo; Neoplasias Pancreáticas

Palavras-chave

ACAGT-007a (GT-7); AKT signaling; ERK MAPK; KRAS; apoptosis; pancreatic cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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