Control of Reactions of Pyruvates by Catalysts: Direct Enantioselective Mannich Reactions of Pyruvates Catalyzed by Amine-based Catalyst Systems.
Org Lett
; 24(9): 1853-1858, 2022 03 11.
Article
em En
| MEDLINE
| ID: mdl-35226512
ABSTRACT
Enantioselective Mannich reactions of pyruvates catalyzed by amine-based catalyst systems, in which pyruvates act as nucleophiles, are reported. The reactions of pyruvates and cyclic sulfonylimines afforded the desired Mannich products, including those bearing tetrasubstituted carbon centers, in high yields with high enantioselectivities in most cases. The selection of the acid used in the amine-based catalyst system was key for the formation of the Mannich products with high enantioselectivities.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piruvatos
/
Aminas
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article