Nanopore Detection of Cancer Biomarkers: A Challenge to Science.
Technol Cancer Res Treat
; 21: 15330338221076669, 2022.
Article
em En
| MEDLINE
| ID: mdl-35229683
ABSTRACT
Cancer is the most complex and leading cause of fatality worldwide. Despite meritorious research in the field of cancer, it is still a substantial threat to human life. In this article, we address a question on the present strategies and manifest the importance of critical biomarkers for cancer screening and early diagnosis before the symptoms appear. However, this goal can only be achieved if scientists will focus on ultra-sensitive detection techniques such as "Nanopore." Nanopore sensing is a simple and rapid single-molecule detection technique that can detect multiple cancer biomarkers in femto-Molar concentrations in real time. Last but not least, we propose a systematic policy to win the war against cancer that is a big challenge to science.
Palavras-chave
cancer; cancer biomarkers; diagnosis Abbreviations DNA, deoxyribonucleic acid; RNA, ribonucleic acid; α-Hemolysin, Alpha Hemolysin; MspA, Mycobacterium Smegmatis porin A; Si3N4, silicon nitride; miRNA, MicroRNA; GSH, glutathione; CD, circular dichroism; FRET: fluorescence resonance energy transfer; early detection; nanopore; screening
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nanoporos
/
Neoplasias
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article