Metformin enhances LDL-cholesterol uptake by suppressing the expression of the pro-protein convertase subtilisin/kexin type 9 (PCSK9) in liver cells.

Ali, Amjad; Unnikannan, Hema; Shafarin, Jasmin; Bajbouj, Khuloud; Taneera, Jalal; Muhammad, Jibran Sualeh; Hasan, Haydar; Salehi, Albert; Awadallah, Samir; Hamad, Mawieh

Ali, Amjad; Unnikannan, Hema; Shafarin, Jasmin; Bajbouj, Khuloud; Taneera, Jalal; Muhammad, Jibran Sualeh; Hasan, Haydar; Salehi, Albert; Awadallah, Samir; Hamad, Mawieh.

Afiliação

Ali A; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Unnikannan H; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Shafarin J; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Bajbouj K; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Taneera J; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Muhammad JS; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Hasan H; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Salehi A; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Awadallah S; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Hamad M; Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.

Endocrine ; 76(3): 543-557, 2022 06.

Article em En | MEDLINE | ID: mdl-35237909

Assuntos

Metformina; Pró-Proteína Convertase 9; Proteínas Quinases Ativadas por AMP/metabolismo; LDL-Colesterol; Células Hep G2; Hepatócitos/metabolismo; Humanos; Fígado/metabolismo; Metformina/farmacologia; Metformina/uso terapêutico; Pró-Proteína Convertase 9/genética; Pró-Proteína Convertase 9/metabolismo; Receptores de LDL/genética; Receptores de LDL/metabolismo; Subtilisina/metabolismo; Subtilisina/farmacologia

Palavras-chave

HNF-1α; LDL-cholesterol; LDLR; Metformin; PCSK9; SREBP2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Proteína Convertase 9 / Metformina Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Proteína Convertase 9 / Metformina Idioma: En Ano de publicação: 2022 Tipo de documento: Article