Post-Transplantation Cyclophosphamide Uniquely Restrains Alloreactive CD4<sup>+</sup> T-Cell Proliferation and Differentiation After Murine MHC-Haploidentical Hematopoietic Cell Transplantation.

Hadjis, Ashley D; Nunes, Natalia S; Khan, Shanzay M; Fletcher, Rochelle E; Pohl, Alessandra de Paula; Venzon, David J; Eckhaus, Michael A; Kanakry, Christopher G

Post-Transplantation Cyclophosphamide Uniquely Restrains Alloreactive CD4⁺ T-Cell Proliferation and Differentiation After Murine MHC-Haploidentical Hematopoietic Cell Transplantation.

Hadjis, Ashley D; Nunes, Natalia S; Khan, Shanzay M; Fletcher, Rochelle E; Pohl, Alessandra de Paula; Venzon, David J; Eckhaus, Michael A; Kanakry, Christopher G.

Afiliação

Hadjis AD; Experimental Transplantation and Immunotherapy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Nunes NS; Experimental Transplantation and Immunotherapy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Khan SM; Experimental Transplantation and Immunotherapy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Fletcher RE; Experimental Transplantation and Immunotherapy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Pohl AP; Experimental Transplantation and Immunotherapy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Venzon DJ; Biostatistics and Data Management Section, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Eckhaus MA; Division of Veterinary Resources, Office of Research Services, National Institutes of Health, Bethesda, MD, United States.
Kanakry CG; Experimental Transplantation and Immunotherapy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Front Immunol ; 13: 796349, 2022.

Article em En | MEDLINE | ID: mdl-35242129

Assuntos

Doença Enxerto-Hospedeiro; Transplante de Células-Tronco Hematopoéticas; Animais; Proliferação de Células; Ciclofosfamida/uso terapêutico; Citarabina; Fatores de Transcrição Forkhead; Doença Enxerto-Hospedeiro/tratamento farmacológico; Doença Enxerto-Hospedeiro/prevenção & controle; Transplante de Células-Tronco Hematopoéticas/métodos; Metotrexato/farmacologia; Camundongos; Linfócitos T Reguladores

Palavras-chave

allogeneic hematopoietic cell transplantation (HCT); alloreactive; bendamustine; graft-versus-host disease (GVHD); haploidentical; methotrexate; post-transplantation cyclophosphamide (PTCy); regulatory (Treg) cell

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco Hematopoéticas / Doença Enxerto-Hospedeiro Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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