Neutralizing antibody responses 300 days after SARS-CoV-2 infection and induction of high antibody titers after vaccination.
Eur J Immunol
; 52(5): 810-815, 2022 05.
Article
em En
| MEDLINE
| ID: mdl-35247269
ABSTRACT
Neutralizing antibodies against SARS-CoV-2 are important to protect against infection and/or disease. Using an assay to detect antibodies directed against the receptor binding domain (RBD) of SARS-CoV-2 Spike, we identified individuals with SARS-CoV-2 infection after an outbreak at a local health institution. All but one COVID-19 patient developed detectable anti-RBD antibodies and 77% had virus neutralizing antibody titers of >125. Antibody levels declined slightly over time. However, we still detected virus neutralizing antibody titers in 64% of the COVID-19 patients at >300 days after infection, demonstrating durability of neutralizing antibody levels after infection. Importantly, full COVID-19 vaccination of these individuals resulted in higher antibody titers compared to fully vaccinated individuals in the absence of prior infection. These data demonstrate long-lived antibody-mediated immunity after SARS-CoV-2 infection, and a clear benefit of two vaccine doses for recovered individuals.
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MEDLINE
Assunto principal:
COVID-19
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En
Ano de publicação:
2022
Tipo de documento:
Article