[Current management and perspectives for locally advanced nasopharyngeal carcinoma]. / État des lieux et perspectives thérapeutiques pour les carcinomes nasopharyngés localement évolués.
Cancer Radiother
; 26(5): 730-735, 2022 Sep.
Article
em Fr
| MEDLINE
| ID: mdl-35249815
ABSTRACT
Nasopharyngeal carcinoma diagnosis is often made at a locally advanced stage (75 to 90% of cases) due to its deep localization. Concomitant radio-chemotherapy is the cornerstone of the treatment of locally advanced forms. The advent of intensity-modulated radiotherapy has improved oncological outcomes and reduced toxicity and is currently the gold standard for irradiation technique. For the locally advanced stage, the addition of induction chemotherapy has become the new standard care according to the latest international recommendations to reduce tumor volumes and act early on micro-metastases. Despite these therapeutic advances, the local and especially distant failure rate remains high. This article reviews current treatment strategies and discuss new approaches and perspectives of locoregional and systemic treatment to reduce treatment failures.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carcinoma
/
Neoplasias Nasofaríngeas
/
Radioterapia de Intensidade Modulada
Idioma:
Fr
Ano de publicação:
2022
Tipo de documento:
Article