Engineering miRNA features into siRNAs: Guide-strand bulges are compatible with gene repression.

Hauptmann, Judith; Hehne, Vivien; Balzer, Melanie; Bethge, Lucas; Wikstrom Lindholm, Marie.

Afiliação

Hauptmann J; Silence Therapeutics GmbH, Robert-Roessle-Strasse 10, 13125 Berlin, Germany.
Hehne V; Silence Therapeutics GmbH, Robert-Roessle-Strasse 10, 13125 Berlin, Germany.
Balzer M; Silence Therapeutics GmbH, Robert-Roessle-Strasse 10, 13125 Berlin, Germany.
Bethge L; Silence Therapeutics GmbH, Robert-Roessle-Strasse 10, 13125 Berlin, Germany.
Wikstrom Lindholm M; Silence Therapeutics GmbH, Robert-Roessle-Strasse 10, 13125 Berlin, Germany.

Mol Ther Nucleic Acids ; 27: 1116-1126, 2022 Mar 08.

Article em En | MEDLINE | ID: mdl-35251767