anti-Markovnikov Iodofluorination of Alkenes.
Chem Asian J
; 17(9): e202200184, 2022 May 02.
Article
em En
| MEDLINE
| ID: mdl-35266316
ABSTRACT
The fluorination of alkenes with electrophilic N-F type reagents usually occurs through a Markovnikov-type addition, and the anti-Markovnikov-type addition may require the use of a transition metal catalyst or an expensive catalyst. Herein we describe a convenient anti-Markovnikov iodofluorination of alkenes with Selectfluor/n Bu4 NI. A wide substrate scope and good functional group tolerance were observed. The process allows for the construction of various C-F bonds, especially tertiary C-F bonds. The remarkable features make this protocol attractive, including convenient operations, simple reaction conditions, and the installation of an iodine atom which provides possibilities for further transformations.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Alcenos
/
Halogenação
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article