A Series of Thiadiazolyl-Benzenesulfonamides Incorporating an Aromatic Tail as Isoform-Selective, Potent Carbonic Anhydrase II/XII Inhibitors.

Banoglu, Erden; Ercanli, Taner; Gür Maz, Tugçe; Vullo, Daniela; Bonardi, Alessandro; Gratteri, Paola; Supuran, Claudiu T

Banoglu, Erden; Ercanli, Taner; Gür Maz, Tugçe; Vullo, Daniela; Bonardi, Alessandro; Gratteri, Paola; Supuran, Claudiu T.

Afiliação

Banoglu E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Taç Sok. No:3 Yenimahalle, 06560, Ankara, Turkey.
Ercanli T; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Taç Sok. No:3 Yenimahalle, 06560, Ankara, Turkey.
Gür Maz T; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Taç Sok. No:3 Yenimahalle, 06560, Ankara, Turkey.
Vullo D; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.
Bonardi A; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.
Gratteri P; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.
Supuran CT; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.

ChemMedChem ; 17(10): e202200056, 2022 05 18.

Article em En | MEDLINE | ID: mdl-35266325

Assuntos

Anidrase Carbônica II; Anidrase Carbônica IX; Inibidores da Anidrase Carbônica; Sulfonamidas; Antígenos de Neoplasias; Anidrase Carbônica II/antagonistas & inibidores; Anidrase Carbônica IX/antagonistas & inibidores; Inibidores da Anidrase Carbônica/farmacologia; Humanos; Isoenzimas; Estrutura Molecular; Relação Estrutura-Atividade; Sulfonamidas/farmacologia; Benzenossulfonamidas

Palavras-chave

Carbonic anhydrase; amide linker benzenesulfonamide; glaucoma; thiadiazole

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Inibidores da Anidrase Carbônica / Anidrase Carbônica II / Anidrase Carbônica IX Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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