Effect modification of body mass index on the association between ovarian cysts and endometrial cancer.
Cancer Epidemiol
; 78: 102129, 2022 06.
Article
em En
| MEDLINE
| ID: mdl-35272258
ABSTRACT
BACKGROUND:
Ovarian cysts represent a common condition among women. Epidemiologic studies are inconsistent in determining if women with cysts are more likely to develop endometrial cancer (EC) regardless of overweight/obesity. We investigated the combined role of cysts and body mass index (BMI) on EC risk.METHODS:
We pooled data from three case-control studies conducted in Italy and Switzerland on 920 women with EC and 1700 controls. The prevalence of cysts was 5% among both cases and controls, with 63% of cases being overweight/obese. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression models, adjusting for potential confounders. We conducted stratified analyses according to BMI, and estimated the interaction between cysts and BMI; we carried out additional analyses according to age at diagnosis of cysts.RESULTS:
Overall, history of cysts was not associated to EC (OR=1.27, 95% CI=0.82-1.97, P = 0.29). Normal weight women reporting cysts had an increased risk of EC (OR=2.49, 95% CI=1.31-4.74), while no such effect was found among overweight/obese women (OR=0.65, 95% CI=0.36-1.18; P for interaction=0.004). The association was limited to women below 65 years of age and was stronger in those who reported cysts at age 48 or older.CONCLUSIONS:
Cysts appeared to be a risk factor for EC in lean women but not in overweight/obese ones; these results are consistent with an effect of cysts and obesity on EC along common pathways.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Cistos Ovarianos
/
Neoplasias do Endométrio
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article