&#945;-Hederin inhibits the platelet activating factor-induced metastasis of HCC cells through disruption of PAF/PTAFR axis cascaded STAT3/MMP-2 expression.

Cao, Linna; Zhang, Yiwei; Mi, Jinxia; Shi, Zhanhao; Fang, Zhaoqin; Jia, Dongwei; Pan, Zhiqiang; Peng, Peike

α-Hederin inhibits the platelet activating factor-induced metastasis of HCC cells through disruption of PAF/PTAFR axis cascaded STAT3/MMP-2 expression.

Cao, Linna; Zhang, Yiwei; Mi, Jinxia; Shi, Zhanhao; Fang, Zhaoqin; Jia, Dongwei; Pan, Zhiqiang; Peng, Peike.

Afiliação

Cao L; School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhang Y; Department of Anesthesiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Mi J; Science and Technology Center, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shi Z; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Fang Z; School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jia D; School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: jiadongwei@fudan.edu.cn.
Pan Z; School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: pzq527@163.com.
Peng P; School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: pengpeike@shutcm.edu.cn.

Pharmacol Res ; 178: 106180, 2022 04.

Article em En | MEDLINE | ID: mdl-35288308

Assuntos

Carcinoma Hepatocelular; Neoplasias Hepáticas; Metaloproteinase 2 da Matriz; Ácido Oleanólico; Fator de Ativação de Plaquetas; Saponinas; Carcinoma Hepatocelular/tratamento farmacológico; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patologia; Linhagem Celular Tumoral; Proteínas de Ligação a DNA/metabolismo; Humanos; Neoplasias Hepáticas/tratamento farmacológico; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; Metaloproteinase 2 da Matriz/metabolismo; Simulação de Acoplamento Molecular; Metástase Neoplásica; Ácido Oleanólico/farmacologia; Fator de Ativação de Plaquetas/antagonistas & inibidores; Fator de Ativação de Plaquetas/metabolismo; Glicoproteínas da Membrana de Plaquetas/metabolismo; Receptores Acoplados a Proteínas G/metabolismo; Fator de Transcrição STAT3; Saponinas/farmacologia; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Cancer metastasis; Hepatocellular carcinoma; Platelet-activating factor; α-Hederin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Oleanólico / Saponinas / Fator de Ativação de Plaquetas / Carcinoma Hepatocelular / Metaloproteinase 2 da Matriz / Neoplasias Hepáticas Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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