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The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition.
Sacco, Michael Dominic; Hu, Yanmei; Gongora, Maura Verenice; Meilleur, Flora; Kemp, Michael Trent; Zhang, Xiujun; Wang, Jun; Chen, Yu.
Afiliação
  • Sacco MD; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
  • Hu Y; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, USA.
  • Gongora MV; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
  • Meilleur F; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC, USA.
  • Kemp MT; Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA.
  • Zhang X; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
  • Wang J; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
  • Chen Y; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, USA. junwang@pharmacy.rutgers.edu.
Cell Res ; 32(5): 498-500, 2022 05.
Article em En | MEDLINE | ID: mdl-35292745
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Idioma: En Ano de publicação: 2022 Tipo de documento: Article