Comparative Study of Vasodilatation After Intra-arterial Nicardipine or Dantrolene Infusion in Animal Model of Cerebral Vasospasm.
Clin Neuroradiol
; 32(4): 1011-1017, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-35294572
ABSTRACT
PURPOSE:
Intra-arterial (IA) infusion of calcium channel blockers (CCBs) has been widely applied in treating medically refractory vasospasm; however, surprisingly little is known regarding their vasodilatory duration. This study was undertaken to compare attributes of nicardipine and dantrolene, focusing on efficacy and capacity for sustained vasodilation.METHODS:
In New Zealand white rabbits (Nâ¯= 22), vasospasm was individually provoked through experimentally induced subarachnoid hemorrhage and confirmed via conventional angiography, grouping animals by IA-infused drug (nicardipine vs. dantrolene). Controls received normal saline. After chemoangioplasty, follow-up angiography was performed at intervals of 1-3â¯h for 6â¯h to compare vasospastic and dilated (i.e., treated) arterial diameters. Drug efficacy, duration of action, and changes in mean arterial pressure (relative to baseline) were analyzed by group.RESULTS:
Compared with controls, effective vasodilation was evident in both nicardipine and dantrolene test groups after IA infusion. Vasodilatory effects of nicardipine peaked at 1â¯h, returning to former vasospastic states at 3â¯h. In dantrolene recipients, vasodilation endured longer, lasting >6â¯h. Only the nicardipine group showed a significant 3h period of lowered blood pressure.CONCLUSION:
Unlike the vasodilatory action of a CCB, sustained for <â¯3â¯h after IA infusion, the effect of dantrolene endured for >â¯6â¯h. This outcome suggests that IA dantrolene infused alone or together with a conventional CCB infusion may be a new means of prolonging vasodilatory effect. Further research is needed to assess durations of IA-infused vasodilatory drug based on perfusion status.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Hemorragia Subaracnóidea
/
Vasoespasmo Intracraniano
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article