Novelty-induced frontal-STN networks in Parkinson's disease.
Cereb Cortex
; 33(2): 469-485, 2022 12 20.
Article
em En
| MEDLINE
| ID: mdl-35297483
ABSTRACT
Novelty detection is a primitive subcomponent of cognitive control that can be deficient in Parkinson's disease (PD) patients. Here, we studied the corticostriatal mechanisms underlying novelty-response deficits. In participants with PD, we recorded from cortical circuits with scalp-based electroencephalography (EEG) and from subcortical circuits using intraoperative neurophysiology during surgeries for implantation of deep brain stimulation (DBS) electrodes. We report three major results. First, novel auditory stimuli triggered midfrontal low-frequency rhythms; of these, 1-4 Hz "delta" rhythms were linked to novelty-associated slowing, whereas 4-7 Hz "theta" rhythms were specifically attenuated in PD. Second, 32% of subthalamic nucleus (STN) neurons were response-modulated; nearly all (94%) of these were also modulated by novel stimuli. Third, response-modulated STN neurons were coherent with midfrontal 1-4 Hz activity. These findings link scalp-based measurements of neural activity with neuronal activity in the STN. Our results provide insight into midfrontal cognitive control mechanisms and how purported hyperdirect frontobasal ganglia circuits evaluate new information.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
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Núcleo Subtalâmico
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Estimulação Encefálica Profunda
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article