Influence of Hydrophobicity in the Hydrophilic Region of Cationic Lipids on Enhancing Nucleic Acid Delivery and Gene Editing.

Rapaka, Hithavani; Manturthi, Shireesha; Arjunan, Porkizhi; Venkatesan, Vigneshwaran; Thangavel, Saravanabhavan; Marepally, Srujan; Patri, Srilakshmi V

Rapaka, Hithavani; Manturthi, Shireesha; Arjunan, Porkizhi; Venkatesan, Vigneshwaran; Thangavel, Saravanabhavan; Marepally, Srujan; Patri, Srilakshmi V.

Afiliação

Rapaka H; National Institute of Technology Warangal, Warangal, Telangana 506004, India.
Manturthi S; National Institute of Technology Warangal, Warangal, Telangana 506004, India.
Arjunan P; Christian Medical College, Centre for Stem Cell Research, Vellore, Tamilnadu 632001, India.
Venkatesan V; Christian Medical College, Centre for Stem Cell Research, Vellore, Tamilnadu 632001, India.
Thangavel S; Christian Medical College, Centre for Stem Cell Research, Vellore, Tamilnadu 632001, India.
Marepally S; Christian Medical College, Centre for Stem Cell Research, Vellore, Tamilnadu 632001, India.
Patri SV; National Institute of Technology Warangal, Warangal, Telangana 506004, India.

ACS Appl Bio Mater ; 5(4): 1489-1500, 2022 04 18.

Article em En | MEDLINE | ID: mdl-35297601

Assuntos

Ácidos Nucleicos; Aminoácidos/química; Cátions/química; Edição de Genes; Técnicas de Transferência de Genes; Interações Hidrofóbicas e Hidrofílicas; Lipídeos/química; Fenilalanina; Triazóis; Triptofano; alfa-Tocoferol/química

Palavras-chave

cationic lipids; endosomal escape; gene editing; non-viral nucleic acid delivery; α-tocopherol

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Nucleicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Nucleicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article