Ropanicant (SUVN-911), an &#945;4ß2 nicotinic acetylcholine receptor antagonist intended for the treatment of depressive disorders: pharmacological, behavioral, and neurochemical characterization.

Nirogi, Ramakrishna; Abraham, Renny; Jayarajan, Pradeep; Goura, Venkatesh; Kallepalli, Rajesh; Medapati, Rajesh Babu; Tadiparthi, Jayaprakash; Goyal, Vinod Kumar; Pandey, Santosh Kumar; Subramanian, Ramkumar; Petlu, Surendra; Thentu, Jagadeesh Babu; Palacharla, Veera Raghava Chowdary; Gagginapally, Shankar Reddy; Mohammed, Abdul Rasheed; Jasti, Venkat

Ropanicant (SUVN-911), an α4ß2 nicotinic acetylcholine receptor antagonist intended for the treatment of depressive disorders: pharmacological, behavioral, and neurochemical characterization.

Nirogi, Ramakrishna; Abraham, Renny; Jayarajan, Pradeep; Goura, Venkatesh; Kallepalli, Rajesh; Medapati, Rajesh Babu; Tadiparthi, Jayaprakash; Goyal, Vinod Kumar; Pandey, Santosh Kumar; Subramanian, Ramkumar; Petlu, Surendra; Thentu, Jagadeesh Babu; Palacharla, Veera Raghava Chowdary; Gagginapally, Shankar Reddy; Mohammed, Abdul Rasheed; Jasti, Venkat.

Afiliação

Nirogi R; Suven Life Sciences Ltd, Hyderabad, 500034, India. nvsrk@suven.com.
Abraham R; Suven Life Sciences Ltd, Hyderabad, 500034, India.
Jayarajan P; Suven Life Sciences Ltd, Hyderabad, 500034, India.
Goura V; Suven Life Sciences Ltd, Hyderabad, 500034, India.
Kallepalli R; Suven Life Sciences Ltd, Hyderabad, 500034, India.
Medapati RB; Suven Life Sciences Ltd, Hyderabad, 500034, India.
Tadiparthi J; Suven Life Sciences Ltd, Hyderabad, 500034, India.
Goyal VK; Suven Life Sciences Ltd, Hyderabad, 500034, India.
Pandey SK; Suven Life Sciences Ltd, Hyderabad, 500034, India.
Subramanian R; Suven Life Sciences Ltd, Hyderabad, 500034, India.
Petlu S; Suven Life Sciences Ltd, Hyderabad, 500034, India.
Thentu JB; Suven Life Sciences Ltd, Hyderabad, 500034, India.
Palacharla VRC; Suven Life Sciences Ltd, Hyderabad, 500034, India.
Gagginapally SR; Suven Life Sciences Ltd, Hyderabad, 500034, India.
Mohammed AR; Suven Life Sciences Ltd, Hyderabad, 500034, India.
Jasti V; Suven Life Sciences Ltd, Hyderabad, 500034, India.

Psychopharmacology (Berl) ; 239(7): 2215-2232, 2022 Jul.

Article em En | MEDLINE | ID: mdl-35298691

Assuntos

Antidepressivos; Transtorno Depressivo; Antagonistas Nicotínicos; Anedonia; Animais; Antidepressivos/farmacologia; Fator Neurotrófico Derivado do Encéfalo; Citalopram/farmacologia; Transtorno Depressivo/tratamento farmacológico; Modelos Animais de Doenças; Camundongos; Antagonistas Nicotínicos/farmacologia; Ratos; Receptores Nicotínicos; Serotonina; Sacarose; Natação

Palavras-chave

Antidepressant; Brain-derived neurotrophic factor; Forced swimming test; Ionized calcium-binding adaptor molecule 1; Nicotinic receptors; Reduction in submissive behavior assay; Ropanicant; Serotonin; α4ß2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antagonistas Nicotínicos / Transtorno Depressivo / Antidepressivos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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