Drug Transporters ABCB1 (P-gp) and OATP, but not Drug-Metabolizing Enzyme CYP3A4, Affect the Pharmacokinetics of the Psychoactive Alkaloid Ibogaine and its Metabolites.

F Martins, Margarida L; Heydari, Paniz; Li, Wenlong; Martínez-Chávez, Alejandra; Venekamp, Nikkie; Lebre, Maria C; Lucas, Luc; Beijnen, Jos H; Schinkel, Alfred H

F Martins, Margarida L; Heydari, Paniz; Li, Wenlong; Martínez-Chávez, Alejandra; Venekamp, Nikkie; Lebre, Maria C; Lucas, Luc; Beijnen, Jos H; Schinkel, Alfred H.

Afiliação

F Martins ML; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Heydari P; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Li W; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Martínez-Chávez A; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Venekamp N; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Lebre MC; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Lucas L; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Beijnen JH; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
Schinkel AH; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands.