Resistance-Guided Mining of Bacterial Genotoxins Defines a Family of DNA Glycosylases.

Bradley, Noah P; Wahl, Katherine L; Steenwyk, Jacob L; Rokas, Antonis; Eichman, Brandt F

Bradley, Noah P; Wahl, Katherine L; Steenwyk, Jacob L; Rokas, Antonis; Eichman, Brandt F.

Afiliação

Bradley NP; Department of Biological Sciences, Vanderbilt Universitygrid.152326.1, Nashville, Tennessee, USA.
Wahl KL; Department of Biological Sciences, Vanderbilt Universitygrid.152326.1, Nashville, Tennessee, USA.
Steenwyk JL; Department of Biological Sciences, Vanderbilt Universitygrid.152326.1, Nashville, Tennessee, USA.
Rokas A; Department of Biological Sciences, Vanderbilt Universitygrid.152326.1, Nashville, Tennessee, USA.
Eichman BF; Department of Biomedical Informatics, Vanderbilt Universitygrid.152326.1 School of Medicine, Nashville, Tennessee, USA.

mBio ; 13(2): e0329721, 2022 04 26.

Article em En | MEDLINE | ID: mdl-35311535

Assuntos

Produtos Biológicos; DNA Glicosilases; Streptomyces; Alquilantes; Antibacterianos/metabolismo; Produtos Biológicos/metabolismo; DNA; Adutos de DNA; DNA Glicosilases/genética; DNA Glicosilases/metabolismo; Mutagênicos; Streptomyces/genética; Streptomyces/metabolismo

Palavras-chave

AlkZ; DNA cross-link; DNA glycosylase; DNA repair; HTH_42; Streptomyces; biosynthetic gene cluster; genotoxin; intecalator; natural product; phylogenetic tree; secondary metabolism; self-resistance

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptomyces / Produtos Biológicos / DNA Glicosilases Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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