Amide proton transfer imaging in stroke.
NMR Biomed
; 36(6): e4734, 2023 06.
Article
em En
| MEDLINE
| ID: mdl-35322482
ABSTRACT
Amide proton transfer (APT) imaging, a variant of chemical exchange saturation transfer MRI, has shown promise in detecting ischemic tissue acidosis following impaired aerobic metabolism in animal models and in human stroke patients due to the sensitivity of the amide proton exchange rate to changes in pH within the physiological range. Recent studies have demonstrated the possibility of using APT-MRI to detect acidosis of the ischemic penumbra, enabling the assessment of stroke severity and risk of progression, monitoring of treatment progress, and prognostication of clinical outcome. This paper reviews current APT imaging methods actively used in ischemic stroke research and explores the clinical aspects of ischemic stroke and future applications for these methods.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acidose
/
Acidente Vascular Cerebral
/
AVC Isquêmico
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article