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Selective Targeting of Protein Kinase C (PKC)-θ Nuclear Translocation Reduces Mesenchymal Gene Signatures and Reinvigorates Dysfunctional CD8+ T Cells in Immunotherapy-Resistant and Metastatic Cancers.
Dunn, Jenny; McCuaig, Robert D; Tan, Abel H Y; Tu, Wen Juan; Wu, Fan; Wagstaff, Kylie M; Zafar, Anjum; Ali, Sayed; Diwakar, Himanshu; Dahlstrom, Jane E; Bean, Elaine G; Forwood, Jade K; Tsimbalyuk, Sofiya; Cross, Emily M; Hardy, Kristine; Bain, Amanda L; Ahern, Elizabeth; Dolcetti, Riccardo; Mazzieri, Roberta; Yip, Desmond; Eastgate, Melissa; Malik, Laeeq; Milburn, Peter; Jans, David A; Rao, Sudha.
Afiliação
  • Dunn J; Gene Regulation and Translational Medicine Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
  • McCuaig RD; Melanie Swan Memorial Translational Centre, Faculty of Science and Technology, University of Canberra, Canberra, ACT 2617, Australia.
  • Tan AHY; Gene Regulation and Translational Medicine Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
  • Tu WJ; Melanie Swan Memorial Translational Centre, Faculty of Science and Technology, University of Canberra, Canberra, ACT 2617, Australia.
  • Wu F; Melanie Swan Memorial Translational Centre, Faculty of Science and Technology, University of Canberra, Canberra, ACT 2617, Australia.
  • Wagstaff KM; Gene Regulation and Translational Medicine Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
  • Zafar A; Melanie Swan Memorial Translational Centre, Faculty of Science and Technology, University of Canberra, Canberra, ACT 2617, Australia.
  • Ali S; Melanie Swan Memorial Translational Centre, Faculty of Science and Technology, University of Canberra, Canberra, ACT 2617, Australia.
  • Diwakar H; Cancer Targeting and Nuclear Therapeutics Lab, Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3800, Australia.
  • Dahlstrom JE; Melanie Swan Memorial Translational Centre, Faculty of Science and Technology, University of Canberra, Canberra, ACT 2617, Australia.
  • Bean EG; Medical Oncology, St John of God Midland Public and Private Hospitals, Perth, WA 6056, Australia.
  • Forwood JK; Woden Specialist Medical Centre, I-MED Radiology Network, Canberra, ACT 2606, Australia.
  • Tsimbalyuk S; Anatomical Pathology, ACT Pathology, The Canberra Hospital, Canberra Health Services, Canberra, ACT 2605, Australia.
  • Cross EM; ANU Medical School, College of Health and Medicine, The Australian National University, Canberra, ACT 0200, Australia.
  • Hardy K; The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia.
  • Bain AL; Anatomical Pathology, ACT Pathology, The Canberra Hospital, Canberra Health Services, Canberra, ACT 2605, Australia.
  • Ahern E; School of Dentistry and Medical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia.
  • Dolcetti R; School of Dentistry and Medical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia.
  • Mazzieri R; School of Dentistry and Medical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia.
  • Yip D; Melanie Swan Memorial Translational Centre, Faculty of Science and Technology, University of Canberra, Canberra, ACT 2617, Australia.
  • Eastgate M; Gene Regulation and Translational Medicine Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
  • Malik L; Department of Medical Oncology, Monash Health and Monash University, Melbourne, VIC 3168, Australia.
  • Milburn P; Cancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
  • Jans DA; Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
  • Rao S; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 3010, Australia.
Cancers (Basel) ; 14(6)2022 Mar 21.
Article em En | MEDLINE | ID: mdl-35326747
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article