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Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents.
Skwarczynski, Mariusz; Bashiri, Sahra; Yuan, Ye; Ziora, Zyta M; Nabil, Osama; Masuda, Keita; Khongkow, Mattaka; Rimsueb, Natchanon; Cabral, Horacio; Ruktanonchai, Uracha; Blaskovich, Mark A T; Toth, Istvan.
Afiliação
  • Skwarczynski M; School of Chemistry and Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Bashiri S; School of Chemistry and Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Yuan Y; Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Ziora ZM; Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Nabil O; Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
  • Masuda K; Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
  • Khongkow M; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong 1, Klong Luang 12120, Pathumthani, Thailand.
  • Rimsueb N; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong 1, Klong Luang 12120, Pathumthani, Thailand.
  • Cabral H; Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
  • Ruktanonchai U; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong 1, Klong Luang 12120, Pathumthani, Thailand.
  • Blaskovich MAT; Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Toth I; School of Chemistry and Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Antibiotics (Basel) ; 11(3)2022 Mar 18.
Article em En | MEDLINE | ID: mdl-35326875
ABSTRACT
The development of effective treatments against infectious diseases is an extensive and ongoing process due to the rapid adaptation of bacteria to antibiotic-based therapies. However, appropriately designed activity enhancers, including antibiotic delivery systems, can increase the effectiveness of current antibiotics, overcoming antimicrobial resistance and decreasing the chance of contributing to further bacterial resistance. The activity/delivery enhancers improve drug absorption, allow targeted antibiotic delivery, improve their tissue and biofilm penetration and reduce side effects. This review provides insights into various antibiotic activity enhancers, including polymer, lipid, and silver-based systems, designed to reduce the adverse effects of antibiotics and improve formulation stability and efficacy against multidrug-resistant bacteria.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article