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Calorie restriction changes the anxiety-like behaviour of ageing male Wistar rats in an onset- and duration-dependent manner.
Prvulovic, Milica; Todorovic, Smilja; Milanovic, Desanka; Jovic, Milena; Vujovic, Predrag; Kanazir, Selma; Mladenovic, Aleksandra.
Afiliação
  • Prvulovic M; Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic "- National Institute of the Republic of Serbia, University of Belgrade, Bul.D. Stefana 142, 11000 Belgrade, Serbia. Electronic address: milica.prvulovic@ibiss.bg.ac.rs.
  • Todorovic S; Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic "- National Institute of the Republic of Serbia, University of Belgrade, Bul.D. Stefana 142, 11000 Belgrade, Serbia. Electronic address: smilja.pracer@ibiss.bg.ac.rs.
  • Milanovic D; Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic "- National Institute of the Republic of Serbia, University of Belgrade, Bul.D. Stefana 142, 11000 Belgrade, Serbia. Electronic address: desan@ibiss.bg.ac.rs.
  • Jovic M; Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic "- National Institute of the Republic of Serbia, University of Belgrade, Bul.D. Stefana 142, 11000 Belgrade, Serbia. Electronic address: milena.jovic@ibiss.bg.ac.rs.
  • Vujovic P; Department of Comparative Physiology and Ecophysiology, Institute for Physiology and Biochemistry "Ivan Djaja", Faculty of Biology, University of Belgrade, Studentski trg 16, 11000 Belgrade, Serbia. Electronic address: predragv@bio.bg.ac.rs.
  • Kanazir S; Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic "- National Institute of the Republic of Serbia, University of Belgrade, Bul.D. Stefana 142, 11000 Belgrade, Serbia. Electronic address: selkan@ibiss.bg.ac.rs.
  • Mladenovic A; Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic "- National Institute of the Republic of Serbia, University of Belgrade, Bul.D. Stefana 142, 11000 Belgrade, Serbia. Electronic address: anamikos@ibiss.bg.ac.rs.
Mech Ageing Dev ; 204: 111666, 2022 06.
Article em En | MEDLINE | ID: mdl-35331743
ABSTRACT
Although initially recognized as a universally beneficial approach for the prevention of age-related impairments, the outcome of calorie restriction (CR) is now known to depend on several factors, most notably the age of the subject at the CR commencement, and CR duration. We aimed to examine if and how CR affects anxiety-like behaviour when it is introduced at middle age and late middle age. In addition, as the dopaminergic system is one of the main neurotransmitter systems involved in controlling anxiety, we examined the expression of dopamine receptors (D1R, D2R) in the cortex, striatum, and mesencephalon of male Wistar rats of varying ages. The study was performed on rats fed ad libitum (AL) or exposed to calorie restriction (60% of AL intake). Open field and light-dark tests were used to study anxiety-like behaviour, while PCR and Western blot were used to examine the expression of dopamine receptors. Calorie restriction implemented at middle-age led to variable outcomes on anxiety-like behaviour, while CR implemented at late middle age increased anxiety and decreased the availability of D2R levels in the cortex and mesencephalon. Taken together, these results advise caution when implementing calorie restriction late in life.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ansiedade / Envelhecimento / Restrição Calórica Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ansiedade / Envelhecimento / Restrição Calórica Idioma: En Ano de publicação: 2022 Tipo de documento: Article