Acetic Acid as Processing Aid Dramatically Improves Organic Solvent Solubility of Weakly Basic Drugs for Spray Dried Dispersion Manufacture.

Adam, Molly S; Miller, Warren K; Pluntze, Amanda M; Stewart, Aaron M; Cape, Jonathan L; Grass, Michael E; Morgen, Michael M

Adam, Molly S; Miller, Warren K; Pluntze, Amanda M; Stewart, Aaron M; Cape, Jonathan L; Grass, Michael E; Morgen, Michael M.

Afiliação

Adam MS; Global Research & Development, Lonza, Bend, OR 97703, USA.
Miller WK; Global Research & Development, Lonza, Bend, OR 97703, USA.
Pluntze AM; Global Research & Development, Lonza, Bend, OR 97703, USA.
Stewart AM; Global Research & Development, Lonza, Bend, OR 97703, USA.
Cape JL; Global Research & Development, Lonza, Bend, OR 97703, USA.
Grass ME; Global Research & Development, Lonza, Bend, OR 97703, USA.
Morgen MM; Global Research & Development, Lonza, Bend, OR 97703, USA.

Pharmaceutics ; 14(3)2022 Mar 02.

Article em En | MEDLINE | ID: mdl-35335931

Palavras-chave

acetic acid; amorphous solid dispersion; brick dust compounds; ionized drug; manufacturability; pharmaceuticals; poor solubility; processing aid; spray drying; sustainable

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article