COVID-19 Vaccination Limits Systemic Danger Signals in SARS-CoV-2 Infected Patients.
Viruses
; 14(3)2022 03 09.
Article
em En
| MEDLINE
| ID: mdl-35336973
ABSTRACT
Vaccination with an mRNA COVID-19 vaccine determines not only a consistent reduction in the risk of SARS-CoV-2 infection but also contributes to disease attenuation in infected people. Of note, hyperinflammation and damage-associated molecular patterns (DAMPs) have been clearly associated with severe illness and poor prognosis in COVID-19 patients. In this report, we revealed a significant reduction in the levels of IL-1ß and DAMPs molecules, as S100A8 and High Mobility Group Protein B1 (HMGB1), in vaccinated patients as compared to non-vaccinated ones. COVID-19 vaccination indeed prevents severe clinical manifestations in patients and limits the release of systemic danger signals in SARS-CoV-2 infected people.
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Base de dados:
MEDLINE
Assunto principal:
Vacinas Virais
/
COVID-19
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article