Drug-free contact lens based on quaternized chitosan and tannic acid for bacterial keratitis therapy and corneal repair.
Carbohydr Polym
; 286: 119314, 2022 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-35337520
ABSTRACT
Bacterial keratitis (BK) and related inflammatory diseases causes irreversible damage to the corneal tissue. In this study, a novel polyacrylamide semi-interpenetrating network hydrogel including quaternized chitosan and tannic acid (PAM-QCS-TA) were used to construct a novel antibacterial and antioxidant contact lens. The obtained hydrogels showed high water content (>85%), swelling resistance, light transmittance (>90%) and adjustable mechanical property. Both quantitative and qualitative antibacterial experiments against Staphylococcus aureus and Escherichia coli (E. coli) indicated excellent sterilization function especially against E. coli (almost 100%). Due to the presence of tannin acid, it showed obvious antioxidant properties, which relieved oxidative stress and protect cells from reactive oxygen species-induced cytotoxicity. Animal experiments also indicated the shortened treatment time of BK (only 3 days) as well as the protection of eye tissue structure. Therefore, such drug-free antibacterial and antioxidant contact lens avoiding the development of drug resistance is a potential candidate in ocular infectious and inflammatory diseases treatment.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Lentes de Contato
/
Quitosana
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Ceratite
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article