Significance of plasma fibrinogen and malondialdehyde in the post-inflammatory period in patients with cystic fibrosis.
Bratisl Lek Listy
; 123(3): 149-152, 2022.
Article
em En
| MEDLINE
| ID: mdl-35343745
ABSTRACT
OBJECTIVES:
Evaluation of selected inflammatory parameters and serum malondialdehyde (MDA) significance in the post-inflammatory period in adult patients with cystic fibrosis.BACKGROUND:
Laboratory biomarkers can be integrated into clinical practice as part of monitoring the effectiveness of treatment.METHODS:
After recovery from an acute exacerbation of lung infection, selected inflammatory parameters (fibrinogen, IL-1, IL-6, SAA, hs-CRP) and serum MDA were examined in 30 adult patients with cystic fibrosis. Their correlation with FEV1, frequency and duration of subsequent hospitalizations and 6-year prognosis in terms of mortality or need for lung transplantation was evaluated.RESULTS:
FEV1 negatively correlated with fibrinogen, but positively with MDA. No significant correlation with hs-CRP, IL-1, IL-6 and SAA was recorded. Plasma fibrinogen predicted the frequency and duration of subsequent hospitalizations. The 6-year prognosis was negatively associated with plasma fibrinogen whereas its association with MDA was positive. However, the prognosis of patients in the multivariate analysis was significantly associated only with FEV1.CONCLUSION:
Plasma fibrinogen examined in the post-inflammatory period is a marker of lung damage in patients with cystic fibrosis and can be used to predict the prognosis. The positive correlation of serum MDA with FEV1 in the post-inflammatory period may be important to the interpretation of treatment interventions (Tab. 3, Fig. 2, Ref. 17).Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Fibrinogênio
/
Fibrose Cística
/
Malondialdeído
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article