Hydroxychloroquine attenuates neuroinflammation following traumatic brain injury by regulating the TLR4/NF-&#954;B signaling pathway.

Hu, Jian; Wang, Xue; Chen, Xiongjian; Fang, Yani; Chen, Kun; Peng, Wenshuo; Wang, Zhengyi; Guo, Kaiming; Tan, Xianxi; Liang, Fei; Lin, Li; Xiong, Ye

Hydroxychloroquine attenuates neuroinflammation following traumatic brain injury by regulating the TLR4/NF-κB signaling pathway.

Hu, Jian; Wang, Xue; Chen, Xiongjian; Fang, Yani; Chen, Kun; Peng, Wenshuo; Wang, Zhengyi; Guo, Kaiming; Tan, Xianxi; Liang, Fei; Lin, Li; Xiong, Ye.

Afiliação

Hu J; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Wang X; School of Pharmaceutical Sciences, Wenzhou Medical University, University-town, Wenzhou, 325035, China.
Chen X; School of Pharmaceutical Sciences, Wenzhou Medical University, University-town, Wenzhou, 325035, China.
Fang Y; School of Pharmaceutical Sciences, Wenzhou Medical University, University-town, Wenzhou, 325035, China.
Chen K; School of Pharmaceutical Sciences, Wenzhou Medical University, University-town, Wenzhou, 325035, China.
Peng W; School of Pharmaceutical Sciences, Wenzhou Medical University, University-town, Wenzhou, 325035, China.
Wang Z; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Guo K; School of Pharmaceutical Sciences, Wenzhou Medical University, University-town, Wenzhou, 325035, China.
Tan X; School of Pharmaceutical Sciences, Wenzhou Medical University, University-town, Wenzhou, 325035, China.
Liang F; School of Pharmaceutical Sciences, Wenzhou Medical University, University-town, Wenzhou, 325035, China.
Lin L; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Xiong Y; School of Pharmaceutical Sciences, Wenzhou Medical University, University-town, Wenzhou, 325035, China. 18376779598@163.com.

J Neuroinflammation ; 19(1): 71, 2022 Mar 28.

Article em En | MEDLINE | ID: mdl-35346242

Assuntos

Lesões Encefálicas Traumáticas; NF-kappa B; Animais; Lesões Encefálicas Traumáticas/complicações; Lesões Encefálicas Traumáticas/tratamento farmacológico; Lesões Encefálicas Traumáticas/metabolismo; Modelos Animais de Doenças; Hidroxicloroquina/farmacologia; Hidroxicloroquina/uso terapêutico; Camundongos; Camundongos Endogâmicos C57BL; NF-kappa B/metabolismo; Doenças Neuroinflamatórias; Transdução de Sinais; Receptor 4 Toll-Like/metabolismo

Palavras-chave

Hydroxychloroquine; Microglia activation; Neuroinflammation; TBI; TLR4/NF-κB

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Lesões Encefálicas Traumáticas Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Lesões Encefálicas Traumáticas Idioma: En Ano de publicação: 2022 Tipo de documento: Article