Estimation of the Regenerative Potential of para-Tyrosol in the Model of Testicular Insufficiency Caused by Damage to Spermatogonial Stem Cells.
Bull Exp Biol Med
; 172(5): 632-636, 2022 Mar.
Article
em En
| MEDLINE
| ID: mdl-35352256
ABSTRACT
The regenerative properties of p-tyrosol were investigated in a model of testicular insufficiency caused by a toxic effect on spermatogonial stem cells (single administration of paclitaxel in the maximum tolerable dose). Against the background of p-tyrosol administration, we observed an increase in the number of normal spermatogonia and Sertoli cells, stimulation of spermatogenesis, and renewal of the spermatogenic tissue. The treatment with p-tyrosol also led to a decrease in DNA damage in cells of the testicular tissue. These changes were accompanied by a decrease in the level of free radicals, an increase in antioxidant protection, and normalization of the redox potential.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Espermatogônias
/
Testículo
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article